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| Scientific Info | | Grape seed extract kills cancer cells and enhances growth of normal cells. | Mol Cell Biochem. 1999 Jun;196(1-2):99-108.
The cytotoxic effects of a novel IH636 grape seed proanthocyanidin extract on cultured human cancer cells.
Ye X, Krohn RL, Liu W, Joshi SS, Kuszynski CA, McGinn TR, Bagchi M, Preuss HG, Stohs SJ, Bagchi D.
These data demonstrate that grape seed proanthocyanidin extract exhibited cytotoxicity towards some cancer cells, while enhancing the growth and viability of the normal cells which were examined. |
| Grape seed extract increases bone mass and strength in rats. | J Musculoskelet Neuronal Interact. 2004 Sep;4(3):301-7.
Effects of grape seed proanthocyanidins extract on rat mandibular condyle.
Kojima K, Maki K, Tofani I, Kamitani Y, Kimura M.
These results suggest that grape seed proanthocyanidins extract treatment would increase both bone mass and bone strength on the rat mandibular condyles. |
| Grape seed extract is beneficial for sun protection and chronic pancreatitis in humans. | Toxicology. 2000 Aug 7;148(2-3):187-97.
Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention.
Bagchi D, Bagchi M, Stohs SJ, Das DK, Ray SD, Kuszynski CA, Joshi SS, Pruess HG.
Topical application of grape seed proanthocyanidin extract (GSPE) enhances sun protection factor in human volunteers, as well as supplementation of GSPE ameliorates chronic pancreatitis in humans. These results demonstrate that GSPE provides excellent protection against oxidative stress and free radical-mediated tissue injury. |
| Grape seed extract protects brain cells of rats against oxidative stress. | Nitric Oxide. 2001 Apr;5(2):137-49.
Protection of primary glial cells by grape seed proanthocyanidin extract against nitrosative/oxidative stress.
Roychowdhury S, Wolf G, Keilhoff G, Bagchi D, Horn T.
It was shown that, in addition to its antioxidative property, grape seed proanthocyanidin extract (GSPE) enhances low-level production of intracellular NO in primary rat astroglial cultures. Furthermore, GSPE pretreatment protects the microglial GSH pool during high output NO production and results in an elevation of the H(2)O(2) tolerance in astroglial cells. |
| Grape Seed - Cellular protection with proanthocyanidins derived from grape seeds | Grape seed proanthocyanidins have been reported to possess a broad spectrum of pharmacological and medicinal properties against oxidative stress
Bagchi D, Bagchi M, Stohs S, et al. Ann N Y Acad Sci 2002;957:260-270. |
| | | | | Supplier: Swiss Herbal Remedies Ltd. | | Brand: Swiss Herbal Remedies Inc. | | Case Size: 24 | | Grape Seed Extract STD 100 mg (Phyto)
60 caps | | | Stock #: 025081 | | | Description: Swiss Herbal’s Grapeseed is a complex of Grapeseed Standardized extract and phosphatidylcholine (LECI-PC) from Lucas Meyer™. Lecithin PC surrounds the Grapeseed extract’s active ingredient, proanthocyanidin, in a 2:1 ratio resulting in a complex with enhanced bioavailability and faster absorption. Grape seed extract is thought to have more antioxidant power than vitamin C, E and betacarotene. The antioxidants in grape seed extract work by protecting the cells against unstable oxygen molecules (free radicals), and binding to collagen - thereby promoting youthful skin, healthy cells, cellular elasticity and flexibility. Grape seed extract contains procyanidolic oligomers (PCOs) which improve blood cirulation and help strengthen blood vessels, which may benefit people with heart disease, cancer and other ailments. PCOs increase blood flow in various vascular disorders, such as: diabetes, varicose veins, leg cramps, arm and leg numbness or tingling, and impotence. Grapeseed extract's positive effects on circulation may also help to improve macular degeneration and cataracts. It is similar to pine bark extract, with a high content of proanthocyanidins (95%). Proanthocyanidins are found in many foods, but freezing, cooking and canning deactivate them. | | Benefits & How it Works: Heart Disease:
The risk for heart attack and stroke may be reduced with this potent antioxidant, which is believed to prevent the plaque development that can clog arteries. A recent study of 38 smokers indicates that PCOs may function as effectively as aspirin in keeping blood cells from sticking together and forming blood clots and the PCOs posed no risk of the gastrointestinal irritation or bleeding generally associated with aspirin. Grape seed oil used to replace other oils in cooking increases HDL ("good") cholesterol by 14% and reduces triglycerides by 15% in just four weeks.
Cancer:
The antioxidants in grape seed extract work hard at helping to control cellular damage, routinely hunting down and neutralizing mutations within the genetic material of cells that could lead to tumor formation. The development and progression of cancers of the lung, breast, stomach, prostate, colon, skin and other body parts may be stalled as a result.
Skin Disease:
Certain components within the skin--collagen, elastin and hyaluronic acid--participate in keeping it healthy. PCOs help keep these substances in good shape by blocking enzymes that might disrupt their chemical structure. In this way, grape seed extract may be useful in treating inflammatory skin conditions such as psoriasis. Its flavonoids also inhibit allergic reactions that can generate such skin problems as eczema.
Fibromyalgia:
Fibromyalgia is an elusive disorder associated with chronic muscle pain and stiffness. The antioxidant power of grape seed extract can help by protecting besieged muscle cells from damage.
Allergies:
As a natural antihistamine, grape seed extract may help to control the sneezing, congestion and other hallmarks of an allergic reaction. The extract also inhibits the release of chemicals called prostaglandins that can generate inflammation during an allergic response. Working synergistically, the nutrient's antihistamine and anti-inflammatory actions can help to keep at bay such allergic responses as hives, hay fever and eczema.
Macular Degeneration & Cataracts:
Grape seed extract improves blood flow in the eye's tiny vessels, where certain eye diseases can cause blockages and impairments that result in vision damage. Cataracts are an example. The extract's antioxidant powers are of particular value in warding off the free-radical damage so frequently cited as the leading cause of macular degeneration.
Eye Strain:
People who stare at computer monitors for extended periods may benefit from taking grape seed extract. The findings of one recent study indicate that 300 mg, taken daily, will ease eyestrain and enhance perception of contrast after just 60 days. | | Dosages & Ingredients: Adults: Take one to two capsules per day or as directed by a physician.
Contains NO added artificial preservatives, colour, milk, wheat, corn or yeast.
Grapeseed Phytolipid 100 mg Complex contains standardized grapeseed extract, powder, and phosphotidylcholine (PC) from Lucas Meyer Soya Lecithin in a specially blended formula which has proven enhanced bioavailability and faster absorption.
Each capsule contains:
Standardized grapeseed extract 95% proanthocyanidins.........................30 mg
Grapeseed powder..........................70 mg
Also contains silica, rice flour,and magnesium stearate in a vapsule composed of gelatin and purified water. | | |
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