| Scientific Info | | Relationship between aldosterone and progesterone in the human menstrual cycle* | Progesterone may directly contribute to increased luteal phase aldosterone production
Szmuilowicz ED, Adler GK, Williams JS, Green DE, Yao TM, Hopkins PN, Seely EW.
Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT.
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| Progesterone reverses the spatial memory enhancements initiated by tonic and cyclic oestrogen therapy in middle-aged ovariectomized female rats. | Progesterone decreased the number of deaths due to tonic estradiol treatment.
Bimonte-Nelson HA, Francis KR, Umphlet CD, Granholm AC.
Department of Psychology, Arizona State University, PO Box 871104, Tempe, AZ 85287, USA
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| | | | | Supplier: NOW Foods (USA) | | Brand: NOW Foods (USA) | | Case Size: 12 | | Progesterone Liposomal Skin Cream
85 g | | | Stock #: 120770 | | | Description: As research continues to link hormone replacement therapy to an increasing number of dangerous side effects, more and more women are turning to progesterone as a more natural way to support healthy hormone levels while reducing the dominance of estrogen. NOW Progesterone Liposomal Cream is a completely safe, natural, pharmaceutical-grade progesterone that includes a balancing blend of herbs from around the world. Thanks to amazing advancements in liposome technology, supporting a woman’s hormonal balance has never been safer, easier or more natural.* | | Benefits & How it Works: Progesterone is a natural hormone produced by the corpeus luteum in women, as well as in smaller amounts by the adrenal glands in both sexes. This antiestrogenic steroid is produced in a woman’s body during the second half of each monthly cycle, from ovulation until menses, and is the dominant hormone during this phase. During this latter phase of menstruation, progesterone keeps the lining of the uterus ready to receive a fertilized ovum. Progesterone is extremely important to a woman’s health and well-being in a number of ways. It promotes the survival and development of the embryo and fetus, acts as a precursor for other steroid hormones, enhances mood, assists the action of thyroid hormones and much, much more. If a woman’s body doesn’t produce proper amounts of progesterone during the second phase of the cycle, then estrogen from the first phase remains, leading to estrogen dominance. Without proper amounts of progesterone to balance estrogen, the unwanted symptoms of menopause and PMS occur, such as hot flashes.
For decades women relied on two different forms of hormone therapy for combating the symptoms of menopause. The first was Estrogen Replacement Therapy (ERT). ERT was first suggested as a treatment for menopause in the ‘60’s. At this time it was believed (erroneously) that menopause was a disease caused by estrogen deficiency. ERT was touted as the magical elixir of youth that could save women from the ravages of aging. For ten years ERT was the treatment of choice for menopausal women, with tragic consequences. A study in 1975 provided strong evidence that women taking estrogen were seven and a half times more likely to contract endometrial cancer, and women who had been taking it for more than seven years were fourteen times more likely. Further investigation showed that estrogen could cause other serious health problems.
With new research illuminating the role of hormones in menopause, manufacturers of estrogen drugs began to focus on the role of progesterone as a mediator of estrogen. They soon created progestin, a synthetic progesterone, and added it to the estrogen treatment regimen as a means to balance estrogen and reduce the risk of endometrial cancer. Hence the unveiling of a new improved treatment called Hormone Replacement Therapy, or HRT. Again, however, problems lurked below the surface. Instead of employing natural progesterone, researchers engineered a synthetic progesterone, to create control of this compound with their patents. Natural source progesterones derived from diosgenin, a steroid from wild yams, couldn’t be patented. Consequently, HRT with synthetic progesterone became the most recommended treatment for symptoms of menopause for the next two decades.
In 1995 the dark underside of HRT was revealed just as it had been with ERT. Researchers discovered that women who were using HRT were 30 to 40 percent more likely to contract breast cancer when taking progestin for more than five years, and women age 60 to 64 were 70 percent more likely to contract breast cancer after more than five years of treatment. The problem was with progestins. In order for them to be patented, progestins had to have a different molecular structure than progesterone as it’s found in the body. This difference led to a multitude of serious side effects.
And so finally, after almost four decades, progesterone is finally getting the attention it so richly deserves. Research shows that the inclusion of progesterone is extremely important in HRT for menopausal women, especially for balancing the effects of estrogen. At menopause, estrogen levels can drop to 40-60% of premenopausal levels, while progesterone levels can drop to zero in certain cases. This is why it’s important for menopausal and post-menopausal women to supplement with progesterone – too much estrogen without progesterone for balance increases the risk of breast cancer and other serious health problems. Progesterone is also a precursor for the production of other steroid hormones important to overall health and well-being.
Menopausal and post-menopausal women aren’t the only ones who can benefit from progesterone supplementation. Pre-menopausal women can benefit as well. Many premenopausal women produce enough estrogen to bring on menstruation, but very little if any progesterone, creating estrogen dominance. This may occur in the 10 to 15 years leading up to menopause. Supplemental progesterone can help balance the ratio of estrogen to progesterone and help reduce the symptoms of PMS.
NOW® Progesterone Liposomal Skin Cream is an excellent source of safe progesterone that’s delivered in an effective skin cream format with a balancing herbal blend to enhance absorption. Because progesterone is a fat-soluble substance, topical application is more effective than oral intake. Each 3 ounce bottle dispenses a carefully measured and recommended 20mg dose per pump and contains 70 pumps per bottle. The healthy alternative for hormonal balancing is available today. As some 20 million women will soon be joining the estimated 30 million women in North America that are already menopausal, it couldn’t have come at a better time.
| | Dosages & Ingredients: Servings per container: 1 full pump (about 1.2 g)
Suggested Use: 1 full pump dispenses about 1.2 g of cream, providing the recommended 20 mg of USP Progesterone. This container yields approximately 70 pumps. Rotate application between abdomen, hands and thighs for best results. FOR MENSTRUATING (OVULATING) AND PERIMENOPAUSAL WOMEN: Use 1X or 2X daily or as needed, starting on the 7th day after the 1st day of menstrual flow through the 27th day. NON-MENSTRUATING OR MENOPAUSAL WOMEN: Apply 1X or 2X daily for a maximum of 25 days. Resume after a 5-day break or as directed by a health practitioner.
Other Ingredients: Purified Water, Aloe Vera (Aloe barbadensis) (Juice from Leaves), Stearyl Alcohol, Ceteareth-20, Avocado Oil (Persea gratissima), Stearic Acid, Glycerin, Progesterone (Micronized and USP Grade), Phospholipids (from Lecithin), Natural Vitamin E (as d-alpha-Tocopherol), Vitamin A (as Retinyl Palmitate), Vitamin B-5 (as Panthenol), Herbal Extract Blend of: Grape Seed, Sarsaparilla Root (Smilax officinalis syn. S. regelii), Rosemary Leaf (Rosmarinus officinalis), Dong Quai Root (Angelica polymorpha var. sinensis), Saw Palmetto Berries (Serenoa repens), Wild Yam Rhizome/Root (Dioscorea villosa), Comfrey Root (Symphytum officinale), Chamomille Flower (Matricaria recutita), Carrot Oil (Daucua carota sativa), Lemon Grass Oil (Cymbopogon citratus) and Xanthan Gum (Xanthomonas campestris).
Warnings: Please discontinue use if irritation or red skin develops, and consult a dermatologist.
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